Abstract
Purpose To compare long-term effects of trabeculectomy on pseudoexfoliation glaucoma (PXG) and primary open-angle glaucoma (POAG). Methods This retrospective case-control study included 53 eyes of PXG and 76 eyes of POAG. Intraocular pressure (IOP), number of antiglaucoma medications used, surgical success rate, and occurrence of complications were observed and statistically analyzed in both groups at 3 and 6 months and at 1, 3, and 5 years after trabeculectomy. Surgical success was defined according to the following 3 criteria: (1) IOP ≤ 21 mmHg; (2) IOP ≤ 18 mmHg; (3) IOP ≤ 15 mmHg. Complete success is defined as patients met these criteria without medical treatment, and qualified success is defined as patients met these criteria with medical treatment (≤3 medications). Cumulative probabilities of success were compared using the Kaplan–Meier survival analysis. Results For the 3 criteria, there were no statistically significant differences in complete and qualified success rates between the two groups at 3 and 6 months after trabeculectomy (P > 0.05). For criterion A, complete success rates in PXG at 3 and 5 years after surgery were lower than those in POAG; for criterion B, complete and qualified success rates in PXG at 3 and 5 years after surgery were lower than those in POAG; for criterion C, complete and qualified success rates in PXG at 1, 3, and 5 years after surgery were lower than those in POAG, the differences were statistically significant (P < 0.05). Conclusions The short-term success rates of both types of glaucoma were similar; however, the long-term success rate of PXG was significantly lower, and it was difficult to achieve long-term control of IOP at a low target level.
Highlights
Pseudoexfoliation glaucoma (PXG) is a common type of secondary glaucoma caused by pseudoexfoliation syndrome (PEX)
Significant progress has been made recently in surgical techniques and postoperative care, excessive scarring and tissue fibrosis caused by proliferation of conjunctival fibroblasts and deposition of extracellular matrix after trabeculectomy are the primary obstacles affecting the formation of filtering blebs and reduction of intraocular pressure (IOP) [8, 9]. is study aimed to evaluate the clinical effects of trabeculectomy on the treatment of PXG and primary open-angle glaucoma (POAG), to calculate the long-term success rates of the surgery in both types of glaucoma, and to explore risk factors affecting the success of the surgery
Its mechanisms primarily include mechanical blockage of the trabecular meshwork caused by intraocular exfoliation substances, dysfunction of the trabecular meshwork, and the coexistence of POAG. e combined action of these three factors leads to the development of PXG [11,12,13]
Summary
Pseudoexfoliation glaucoma (PXG) is a common type of secondary glaucoma caused by pseudoexfoliation syndrome (PEX). Compared with primary open-angle glaucoma (POAG), PXG is characterized by high mean and peak intraocular pressure (IOP), a wide fluctuation range, more severe visual field damage, and faster progression [1,2,3,4,5]. Significant progress has been made recently in surgical techniques and postoperative care, excessive scarring and tissue fibrosis caused by proliferation of conjunctival fibroblasts and deposition of extracellular matrix after trabeculectomy are the primary obstacles affecting the formation of filtering blebs and reduction of IOP [8, 9]. Is study aimed to evaluate the clinical effects of trabeculectomy on the treatment of PXG and POAG, to calculate the long-term success rates of the surgery in both types of glaucoma, and to explore risk factors affecting the success of the surgery Significant progress has been made recently in surgical techniques and postoperative care, excessive scarring and tissue fibrosis caused by proliferation of conjunctival fibroblasts and deposition of extracellular matrix after trabeculectomy are the primary obstacles affecting the formation of filtering blebs and reduction of IOP [8, 9]. is study aimed to evaluate the clinical effects of trabeculectomy on the treatment of PXG and POAG, to calculate the long-term success rates of the surgery in both types of glaucoma, and to explore risk factors affecting the success of the surgery
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
