The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease

Igor A Sobenin,Alexander N Orekhov,Yevgeny A Rabinovich,Valentin V Pryanishnikov,Danik M Martirosyan,Lyudmila M Kunnova

doi:10.1186/1476-511x-9-119

Abstract

The double-blinded placebo-controlled randomized study has been performed in 51 coronary heart disease (CHD) patients to estimate the effects of time-released garlic powder tablets Allicor on the values of 10-year prognostic risk of acute myocardial infarction (fatal and non-fatal) and sudden death, with the respect of secondary CHD prevention. It has been demonstrated that 12-month treatment with Allicor results in the significant decrease of cardiovascular risk by 1.5-fold in men (p < 0.05), and by 1.3-fold in women. The above results were equitable also in terms of relative risks. The main effect that played a role in cardiovascular risk reduction was the decrease in LDL cholesterol by 32.9 mg/dl in men (p < 0.05), and by 27.3 mg/dl in women. Thus, the most significant effects were observed in men, while in women the decrease of cardiovascular risk appeared as a trend that might be due presumably to the insufficient sample size. Since Allicor is the remedy of natural origin, it is safe with the respect to adverse effects and allows even perpetual administration that may be crucial for the secondary prevention of atherosclerotic diseases in CHD patients.

Highlights

Clinical manifestations of atherosclerosis, mainly, coronary heart disease (CHD) and myocardial infarction, remain the leading cause of mortality, morbidity, illness and disability in populations worldwide
In recent years the algorithm for the assessment of multifunctional cardiovascular risk was developed from the data of PROCAM Study, that is suitable for use in CHD patients for the prediction of such cardiovascular events as myocardial infarction and sudden death
The most significant effects were observed in men, while in women the decrease of cardiovascular risk appeared as a tendency that might be due presumably to the insufficient sample size

Summary

Introduction

CHD and myocardial infarction, remain the leading cause of mortality, morbidity, illness and disability in populations worldwide. In recent years the algorithm for the assessment of multifunctional cardiovascular risk was developed from the data of PROCAM Study, that is suitable for use in CHD patients for the prediction of such cardiovascular events as myocardial infarction and sudden death This model of risk assessment allows the estimation of the effects of different drugs that can modify risk factors on the dynamics of changes in cardiovascular risk that incredibly increases with ageing. The social, medical and economical burden of CHD and the other complications of advanced atherosclerosis continue to increase in spite of the evident drop in cardiovascular death rates in the United States of America and several European countries This fact is mostly due to the population ageing, the rapid increase in the prevalence of type 2 diabetes mellitus and obesity. These unfavorable tendencies are characteristic for many industrial and developing countries, CHD remains the major cause of mortality and morbidity in the world.

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