Abstract
Rats thyroidectomized 1 day after birth received daily subcutaneous injections of 1 μg/50 g or 1 μg/l0 g body weight of thyroxine (T<sub>4</sub>) or triiodothyroacetic acid (T<sub>3</sub>AC) from day 6 through day 25. Body and organ growth, whole body metabolic rates, brain and liver succinic dehydrogenase (SDH) activity, day of eye opening, and electrocardiograms (ECG) were investigated. T<sub>3</sub>AC has a biological potency similar to that of T<sub>4</sub> during the critical period of development in the rat with respect to body and organ weight, brain and liver succinic dehydrogenase activity, and day of eye opening. However, T3<sub>A</sub>C was less potent in affecting metabolic rate and heart rate in neonates than was T<sub>4</sub>.
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