Abstract
The wheel running activity of female rats was observed prior to and following thyroidectomy. Thyroidectomy significantly reduced overall activity and increased the interval between activity peaks; thyroid feeding corrected these effects. Thyroid feeding did not correct the effects in ovariectomized rats. The continued administration of estradiol benzoate and progesterone increased activity in ovariectomized-thyroidectomized rats. The results suggest that the activity reduction consequent to thyroidectomy is not a direct result of thyroid removal but an indirect result mediated by altered ovarian functioning.
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