Abstract
The morphology and contractility of the vas deferens to electrical stimulation in vitro was investigated in thyroidectomized rats and rats treated with thyroxine. Thyroidectomy caused atrophy of the smooth muscle, epithelial and mucosal cell layers. Thyroxine treatment produced an overall hypertrophy of the layers, and significant ( P<0.001) positive inotropic effect on both the intrinsic contractility and response of the vas deferens to acetylcholine (Ach) and potassium chloride (KCl) when compared with euthyroid controls. Thyroidectomy had a negative inotropic effect. It also inhibited the contractile responses evoked by Ach and KCl. These findings suggest that thyroid status affects the morphology, which in turn relates directly to the contractility of the vas deferens muscle and its response to contraction evoked by Ach and KCl.
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