Abstract
目的 探讨无花果水提取液的抗疲劳作用及其对一氧化氮合酶活性的影响.方法 80只小鼠随机分成4组:对照组,无花果水提取液低剂量组(0.22g/kg)、中剂量组(0.67g/kg)、高剂量组(2.0g/kg),连续灌胃5周后观察不同剂量的无花果水提取液灌胃的各组小鼠游泳时间,判断无花果水提取液的抗疲劳作用.同时测量小鼠游泳30 min后的血中各种类型的一氧化氮合酶(NOS)的活性.结果 在游泳实验中,中、高剂量组的小鼠的游泳时间分别为(138.70±28.79)min和(56.55±16.64)min,明显高于对照组[(21.00±7.36)min](P＜0.05),低剂量组的游泳时间为(23.43±3.90)min,高于对照组,但差异无显著性.在总NOS(tNOS)方面,低、中、高各剂量组的活性分别为(38.94±10.74)U/L、(31.04±9.14)U/L、(65.34±14.00)U/L,高于对照组的(18.35±4.82)U/L(P＜0.05);在结构型NOS(cNOS)方面,中、高各剂量组的活性分别为(21.04±6.15)U/L和(21.91±6.67)U/L,与对照组的(5.94±1.72)U/L比差异有显著性(P＜0.05),低剂量组的活性为(6.41±1.13)U/L与对照组比差异无显著性;而在诱导型的NOS(iNOS)方面低、中、高各剂量组的活性分别为(32.56±11.39)U/L、(10.51±3.03)U/L和(36.44±15.10)U/L与对照组的(12.78±2.92)U/L比较差异无显著性.结论 无花果水提取液具有一定的抗疲劳作用,该作用可能是通过提高血中的tNOS、cNOS的活性来实现的。
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