Abstract
BackgroundPlatelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection. Several studies and clinical findings have demonstrated that the PRP can accelerate the regeneration and the repair of tissues through the action of the platelet-derived growth factors.Material and methodsOur study aimed to investigate the effects of PRP-gel on the rate of tumor relapse by using a mouse model of Human Fibrosarcoma (HF). The radical resection of tumors of mice was conducted under fluorescence-guidance (FGR) by using MacroFluo microscope, after a primary tumor removal with bright-light surgery (BLS).ResultsIt was found that the lesion recurrence and the tumor growth were reduced in mice treated with PRP observed in each group of treatment (50%) after 30 days from tumor excision, respect to controls (without statistical significance; p = 0.12). The histopathological and immune-histochemical analysis did not report differences in cellular morphology between the tumors of control and PRP-treated mice.ConclusionOur data suggest that PRP-gel, used as an adjuvant treatment for the stimulation of tissue repair and speed up recovery, can impair tumor growth and slow the tumor.
Highlights
Platelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection
Our data suggest that PRP-gel, used as an adjuvant treatment for the stimulation of tissue repair and speed up recovery, can impair tumor growth and slow the tumor
Our data suggest that PRP-gel, used as an adjuvant treatment for the stimulation of tissue repair and speed up recovery, can impair tumor growth and slow the tumor local recurrence after radical surgery of fibrosarcoma
Summary
Platelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection. The clinical management of an imperfect tissue repair caused by surgical or post-surgical cancer treatment, or even congenital or chronic debilitative conditions, is of crucial importance for the structural and the functional reconstruction of tissue and organs [1] For this reason, it’s safe to point out the needing of improving the scientific knowledge of tissue engineering-based procedures in the reconstructive strategies including the autografts, the stem cells and the use of growth factors [2]. Extensive excision can be very invasive and include muscle, tendon, ligament, bone, and joints which often affect limb function For all these reasons, the presence or the absence of residual cancer cells in the surgical area is a crucial point and determines local recurrence by impairing the prognosis and the survival of patients. PRP gel seems to achieve good functional results without promoting local recurrence
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