Abstract
The effects of the putative antiepileptic drug GIZh-298 and the reference standard topiramate on the concentrations of monoamines and their metabolites in the frontal cortex, hypothalamus, nucleus accumbens, striatum, and hippocampus of Wistar rats was investigated using HPLC. It was shown that topiramate at a dose of 100 mg/kg induces an increase in dopamine concentration and a decrease in its metabolism rate in the frontal cortex, a decrease in the level of its metabolites in the dorsal striatum, and an increase in concentrations of dopamine and its metabolites in the hypothalamus 30 minutes after injection. GIZh-298 at a dose of 60 mg/kg caused an increase in the serotonin and dopamine concentration in the frontal cortex and a decrease in the dopamine metabolism rate in the dorsal striatum 30 minutes after injection, which may be considered as one of the components of the antiepileptic effect of this drug.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
