Abstract
ABSTRACT The objective of this study was to investigate the effects of the method and dose of cyclophosphamide (CPA) administration on cashmere shedding. Thirty-two castrated Liaoning cashmere goats were randomly allotted to four groups, with eight replicates in each group. Goats in the four groups were injected intravenously or intramuscularly with CPA at doses of 20 or 25 mg kg−1 body weight (BW), respectively. Feed intake and BW were recorded, and erythrocyte count, hemoglobin content, and cashmere weight were determined. [...]
Highlights
Cyclophosphamide (CPA), as a kind of anticancer drug, can increase nuclear aberrations in hair follicle cells of patients receiving it (Goldberg et al, 1990) and cause hair loss (Stork and Schreffler, 2014)
In fine-wool sheep, studies have already been performed after treatment with CPA, but there is no related study on CPA in cashmere goats, except our previous study, which indicated that intravenous injection with CPA could induce cashmere shedding, increase cashmere weight, and achieve the purpose of concentrated defleecing (Chen et al, 2018)
It can be said that the CPA injection significantly reduced the erythrocyte count and hemoglobin content of cashmere goats in the days immediately following injection, and that the decrease in numbers of erythrocytes was related to the injection method and dose
Summary
Cyclophosphamide (CPA), as a kind of anticancer drug, can increase nuclear aberrations in hair follicle cells of patients receiving it (Goldberg et al, 1990) and cause hair loss (Stork and Schreffler, 2014). Some studies have been conducted on the use of CPA to stimulate wool shedding in fine-wool sheep. These studies have shown that CPA can be used as a chemical defleecing agent for sheep (Dolnick et al, 1969; Reis and Chapman, 1974; Fahmy and Moride, 1984; Lu and Cai, 2007). In fine-wool sheep, studies have already been performed after treatment with CPA, but there is no related study on CPA in cashmere goats, except our previous study, which indicated that intravenous injection with CPA (about 20 mg kg−1 body weight [BW]) could induce cashmere shedding, increase cashmere weight, and achieve the purpose of concentrated defleecing (Chen et al, 2018). Our research team found that intravenous injection can significantly decrease the erythrocyte count and hemoglobin content in Liaoning cashmere goats in the early days of postinjection
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