Abstract
This research evaluated the possible therapeutic potential of Rosa canina as a preventive agent in ischmia/reperfusiom induced acute renal failure in rats. There were three groups (n = 10), in which rats received orally 7 days before induction of ischemia, hydroalcoholic extract of R. canina (500 mg/kg) in R. canina + ischmia/reperfusiom (I/R) group and distilled water in I/R group. In sham group, the renal arteries were not occluded and distilled was administered orally 7 days before surgery. Renal ischemia was induced by both renal arteries occlusion for 45 min followed by 24 h of reperfusion. Blood samples were collected for biochemical analysis, and finally both kidneys were preserved for future histological examination. R. canina treatment reduced total renal histopathological score as well plasma creatinine and blood urea nitrogen levels in R. canina + I/R group in comparison to I/R group. According to these results, R. canina can be useful as a preventive agent against renal damages induced by ischemia/reperfusion injury in rat.
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