Abstract
Objective To study the effects of nuclear factor Kappa B (NF - κB),MCP - 1 and MMP -9 at the early phase of cerebral aneurysm (CA).Methods 24 healthy New Zealand rabbits,half female and half male,were randomly divided into 4 groups:group A ( control group),group B ( 1 week),group C(2 weeks),group D (3 weeks),6 rabbits per-group.The morphologic change of the right common carotid artery and formation of the aneurysm were detected by CT angiography and HE dyeing.Aneurysm samples were collected,and immunohistochemistry and real - time rolymerase chain reaction ( Real - time PCR)used to detect the expression of the proteinum and mRNA of NF - κB,MCP - 1 and MMP -9.Results ( 1 ) After a week,using CT angiography to detect all the 18 experimental rabbits,all of them have found visible fusiform or cystiform aneurysms where the elastase was dropped,and also found that some vessels were obstructed.Aneurysms have not found in all the control group rabbits.The pathological examination of the experimental aneurysms showed that the wall of aneurysm becoming thinner,the internal elastic layers were disrupted or disappeared and the reduced medial vascular smooth muscle cell becoming atrophy or degradation obviously.Inflammatory cell infiltrate were also observed in the control group,but the internal elastic layers degradation and vascular smooth muscle degeneration were not found.(2)The result of immunohistochemistry and Real - time PCR indicate that NF - κB and MCP - 1 reached the peak at 1 week,and decreased at 3 weeks.MMP - 9 was increased gradually.The expression of NF - κB and MCP - 1 were not found in control group.Conclusion NF - κB activation may be one of the initiating agents in the development of the cerebral aneurysm.MCP - 1 and MMP - 9 significantly increased in CA that play an important role in the pathogenesis of cerebral aneurysm(CA). Key words: Aneurysm; Nuclear factor - κB; Monocyte chemotactic protein - 1; MMP -9
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