Abstract
BackgroundReduced serum level of taurine in type 2 diabetes mellitus (T2DM) was shown to be associated with the metabolic alterations and clinical complications of diabetes. Dietary supplementation with taurine may attenuate oxidative stress and inflammatory responses in T2DM as well as alleviate diabetes-induced complications. Hence, this study evaluated the effect of taurine supplementation on oxidative stress and inflammatory biomarkers in patients with T2DM.MethodsFifty patients with T2DM were randomly allocated to two groups to consume either taurine (containing 1000 mg taurine), or placebo (containing crystalline microcellulose) three times per day for 8 weeks. Anthropometric data, dietary intake, serum total antioxidant capacity (TAC), malondialdehyde (MDA), the activities of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), serum levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) were assessed before and after intervention.ResultsThere was a significant increase in SOD (5.1%, p = 0.004) and CAT (4.22%, p = 0.001) after 8 weeks of taurine supplementation. In addition, serum levels of MDA (26.33%, p = 0.001), hs-CRP (16.01%, p = 0.001), and TNF‐α (11.65%, p = 0.03) significantly decreased in the taurine group compared with baseline. Following treatment, the taurine group had fewer serum levels of MDA (p = 0.04), hs-CRP (p = 0.002) and TNF-α (p = 0.006) than the placebo group. Also, a significant increase was observed in SOD (p = 0.007), and CAT (p = 0.001) in the taurine group compared with the placebo group. There were no differences in the serum levels of IL-6 or TAC.ConclusionsThe findings of this study showed that taurine supplementation improved some oxidative stress indices and inflammatory biomarkers in patients with T2DM.Trial registration The protocol of this clinical trial is registered with the Iranian Registry of Clinical Trials (http://www.IRCT.IR, identifier: IRCT20121028011288N16).
Highlights
Reduced serum level of taurine in type 2 diabetes mellitus (T2DM) was shown to be associated with the metabolic alterations and clinical complications of diabetes
Covariance analysis (ANCOVA) revealed a significant increase in superoxide dismutase (SOD) (p = 0.007) and CAT (p = 0.001), as well as a significant reduction in MDA (p = 0.04) in the taurine group compared with the placebo group after adjusting for baseline variables, duration of T2DM, weight, and calorie intake changes; no significant difference was observed in total antioxidant capacity (TAC) (p = 0.06)
To the best of our knowledge, this is the first report of a controlled clinical trial in individuals with T2DM to examine the effects of taurine supplementation on oxidative stress indices and inflammatory biomarkers
Summary
Reduced serum level of taurine in type 2 diabetes mellitus (T2DM) was shown to be associated with the metabolic alterations and clinical complications of diabetes. Dietary supplementation with taurine may attenuate oxidative stress and inflammatory responses in T2DM as well as alleviate diabetes-induced complications. Along with insulin resistance following T2DM, is associated with increased oxidative stress and inflammation in various organs, which can lead to macrovascular and microvascular complications [7]. Mitigating oxidative stress and inflammation are major targets for prevention, management, and treatment of T2DM [9]. This has led researchers to investigate new compounds with strong antioxidant and anti-inflammatory activities
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