Abstract
The Effects of Taurine, Melatonin and N-Acetylcystein on Cadmium Exposure Bone Changes “The Surprising Effect of Taurine”
Highlights
Cadmium, one of the non-essential, heavy metal elements is an important industrial, environmental polluter and known to have various toxic effects on living organisms [14]
The distribution properties and the processes performed in the groups were as follows: Group 1 was the control group with no intervention; Group 2 was the “cadmium exposure” group and the rats in this group were exposed to cadmium for 3 months by drinking 200 mg/L CdCl2 (Fluka, U.S.A.) added water; Group 3 was “cadmium exposure for 3 months + concurrent antioxidant administration” group
The bone mineral density (BMD) values in the group which patients use protective taurine with cadmium (Group IIIa) and use taurine after cadmium exposure as a treatment agent (Group IVa) were significantly lower when compared with all other groups (p
Summary
One of the non-essential, heavy metal elements is an important industrial, environmental polluter and known to have various toxic effects on living organisms [14]. Chronic environmental and occupational exposure to cadmium can result in skeletal system changes, such as osteopenia, osteoporosis and osteomalasia, which all cause increased bone fragility. The negative effect of cadmium on bone has been supported by determined associations between urinary cadmium and increased risk of fractures [1]. When the human organism is exposed to the cadmium, it becomes a powerful competitor of calcium in biochemical processes [24] This competition may play an important role in deterioration of the bone quality. Results: There was no significant difference in terms of bone mineral density values only between control group and cadmium exposure group (p>0.05). 24 hours urine calcium excretion levels were significantly higher in groups which taurine and n-asetylcystein were administered after cadmium exposure. Further studies are needed to clarify this effect of taurine
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