The effects of taurine administration against inflammation in heavily exercised skeletal muscle of rats.

Abstract

AbstractTaurine protects against tissue damage in a variety of models that share inflammation as a common pathogenic feature. Heavy exercise has been shown to cause inflammation and oxidative stress and to damage muscle tissue. High taurine levels are present in skeletal muscle and may play a role as a cellular defense against free radical-mediated damage. The aim of this study was to determine whether taurine injected in the abdomen alters markers of inflammation and free radical damage after varying degrees of heavy exercise. The effect of intra-abdominal administration of taurine 1 h before heavy exercise was examined. On a daily basis for 10 consecutive days, a speed of 20 m/min for 20 min. Muscle damage was associated with an increase in IL-6 and CD68 of the skeletal muscle. The immunoreactivities for IL-6 and CD68 are shown increase in the 20 min heavy exercise group. The increase in IL-6 and CD68 was suppressed in the 20 min heavy exercise group that received an intra-abdominal injection of taurine. Data from this study show that exercise-induced muscle inflammation is reduced in SOL and EDL of rats treated with taurine prior to exercise.KeywordsSkeletal muscleInflammationExerciseCD68IL-6TNF-alpha