Abstract
The antibacterial action of bacitracin is significantly and selectively affected by the presence of surface-active agents as determined by the paper-disk assay, using Micrococcus flavus as the test organism. Potency is enhanced by cationic and nonionic compounds and is decreased by anionic. This effect with benzethonium chloride can be shown in the case of other organisms, namely, Staphylococcus aureus, Streptococcus pyogenes, and Neisseria catarrhalis. Because of the potent antiseptic action of the quaternary ammonium agents, it is suggested that combinations of these with bacitracin may be well suited to the local treatment of infections where greater penetration of the tissue is desired.
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