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Abstract
The effects of subchronical exposure to SO2 (400ppm, 3 hours daily, 28 days) on biochemical and hematological parameters were investigated in guinea pigs. Mostly no significant changes in the values of biochemical parameters and no significant changes in hematological parameters were found. The levels of investigated ions (K+, Na+, Cl-, Ca++, Mg++ and phosphates), proteins (albumines, globulines, total proteins), enzymes (LD, ALT, AST, CK) and other biochemical parameters (urea, creatinine, bilirubin) were not significantly different between groups, with the exception of a significantly higher ALP concentration in the exposed group as compared with controls (2.17 mukat and 1.85 mukat, respectively. It can be concluded that a subchronical exposure to sulphur dioxide mostly did not induce any definite changes in biochemical and hematological parameters in guinea pigs.
Highlights
Environmental pollution is one of the most overwhelming contemporary problems and sulphur dioxide is one of the most common atmospheric pollutants in the Middle Europe region
The aim of the study was to investigate the effects of the subchronical exposure to SO2 on the biochemical and hematological parameters in guinea pigs
Biochemical parameters: Almost no differences in biochemical parameters (Tab. 1) between the SO2 exposed and control group were found, in most of them the tendency towards an elevation could be observed in the former group
Summary
Environmental pollution is one of the most overwhelming contemporary problems and sulphur dioxide is one of the most common atmospheric pollutants in the Middle Europe region. Sulphur dioxide and various particles are emitted into the atmosphere by the burning of fossil fuels and smelting of metals. Many of these particles can promote the conversion of SO2 to the more irritant sulphuric acid [1,10]. The influence of exposure to SO2 on the respiratory tract has been demonstrated in various studies [4, 11, 13]. SO2 dissolves in the fluid lining the airway with the production of sulphite and bisulphite ions. These may react with low molecular weight disulphide groups in proteins. The aim of the study was to investigate the effects of the subchronical exposure to SO2 on the biochemical and hematological parameters in guinea pigs
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