Abstract
Fluoride was the first compound utilized in the fluoridation of drinking water, and still used today t0 for prevent dental caries, sodium fluoride exerts it toxic effects on a different organs . Ovarian follicle considering a fundamental unit of ovary . Objective: the current work aimed to study the toxic effects of sodium fluoride (NaF) on the number and diameters of ovarian follicles . Materials and methods: three groups of adults female albino rats were used .The 1st group as untreated group, 2nd group was treated with 150ppm of sodium fluoride by gavage daily for 90 days, and the third group was treated with sodium fluoride (300ppm) by gavage daily for 90 days. Result :The sodium fluoride had an adverse effects on the number and diameters of ovarian follicle in both concentrated groups dosed group in contrast to the control group, also in addition to inhibit the maturation of ovarian follicle. These results suggest that sodium fluoride damage the structures of ovary, and has adverse effects on the coefficient of the female reproductive system
Highlights
The Effects of Sub-lethal Concentrations of Sodium Fluoride on the Number and Diameters of Ovarian Follicles
Inhibition of the maturation of ovarian follicles. These results suggest that sodium fluoride damage the structures of ovary, and has adverse effects on the coefficient of the female reproductive system
Effects of sub lethal concentration of sodium fluoride on the number of ovarian follicle: Sodium fluoride toxicity on ovarian follicle number was showed in table (1) and Plate (1)
Summary
Lipid which are necessary for the maturation of tissue like uterus endometrium and ovary ( Krassas et al., Excessive exposure to pollutant and toxic 2010 and Bakeer et al, 2021). Metal toxicity like (Abdelsamad et al, 2018) as hormones of the thyroid aluminum, mercury, fluoride and lead effects on the gland effects on the reproductive system at all levels. Fluoride is a cell and granulose cell of the ovary; thyroid common pollutant found in nature Clinical research and trials on experimental animals suggested that, sodium fluoride has adverse effects on the male reproductive system ( AL-Sabaawy and AL-Kaisie, 2020). Due to lack of data on the effects of sodium fluoride on the female reproductive system, the current study was Hadeel, B. AL-Kaisie conducted to evaluate the toxic effects of sub-lethal doses of sodium fluoride on the number and diameters of the ovarian follicles. The ovary's micro morphometric parameters include: (1) number of primordial, primary, secondary, mature and atretic follicles per section / μm, and (2) diameter of follicles/μm
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