Abstract
Steamed ginger ethanolic extract (SGE) is a product with a high 6-shogaol contents and is thought to be more potent than other ginger products. We conducted a 12-week, randomized, double-blind, placebo-controlled clinical trial to determine the effects of SGE on weight and body fat loss. Eighty healthy obese participants were recruited and randomly divided into the SGE and placebo groups. The outcome measures comprised indicators of efficacy (body weight, body mass index, body composition, and blood markers) and safety. Following the supplementation period, mean body weight, body mass index, and body fat level were significantly lower in the SGE group than in the placebo group. No clinically significant changes were observed for any safety parameter. These results suggest that SGE is a potent anti-obesity agent that does not cause significant side effects. Therefore, SGE supplementation combined with lifestyle modification could be effective in the management of body weight and fat mass.
Highlights
Obesity is caused by energy input exceeding energy output over a prolonged period
Mean body weight, body mass index, and body fat level were significantly lower in the Steamed ginger ethanolic extract (SGE) group than in the placebo group
There were no significant differences between the SGE and placebo groups
Summary
Obesity is caused by energy input exceeding energy output over a prolonged period. Obesity leads to many health problems, including hypertension (Jayedi et al, 2018), hyperlipidemia (Klop et al, 2013), diabetes mellitus (Caspard et al, 2018), cardiovascular disease (Kotsis et al, 2018), arthritis (Van Raemdonck et al, 2018), atherosclerosis (Lovren et al, 2015), and cancer (Ottaiano et al, 2018).Diet control and physical activity are the most common methods of preventing obesity. Obesity is caused by energy input exceeding energy output over a prolonged period. Obesity leads to many health problems, including hypertension (Jayedi et al, 2018), hyperlipidemia (Klop et al, 2013), diabetes mellitus (Caspard et al, 2018), cardiovascular disease (Kotsis et al, 2018), arthritis (Van Raemdonck et al, 2018), atherosclerosis (Lovren et al, 2015), and cancer (Ottaiano et al, 2018). Diet control and physical activity are the most common methods of preventing obesity. There is a growing interest in reducing body weight through the use of drugs or supplements in combination with diet control and exercise. The dietary supplements known to reduce body weight may have side effects, as has already been reported for anti-obesity drugs such as appetite suppressants (Krentz et al, 2016). It is necessary to develop healthy functional foods that have anti-obesity effects with no side effects
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