Abstract
The effects of several pharmacologically active amines on gastric emptying rate in male rats has been investigated. Of the compounds tested those with anticholinergic activity; amitriptyline, nortriptyline, imipramine, desmethylimipramine, 3-methylamino-1:1-diphenyl-prop-1-ene and its primary and tertiary amine analogues, dexamphetamine and methylamphetamine, all inhibited gastric emptying of a non-absorbable marker, polyethylene {1,2− 14C} glycol. The compounds with little or no anticholinergic activity did not affect gastric emptying. The activity of the compounds in inhibiting gastric emptying falls in approximately the same order as their anticholinergic activity, lending support to the hypothesis that inhibition of gastric emptying is via in anti-cholinergic mechanism. The results also indicate that absorption is a prerequisite of activity in inhibiting gastric emptying and suggests that these compounds are not acting via a local mechanism.
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