The Effects of some Anticholinergic Compounds on the Infused Urinary Bladder of Unanaesthetized Rabbits

Abstract

Abstract Three anticholinergic compounds, atropine, emeprone, and PR 197 (synthesized at AB Recip, Sweden), were tested for their effects on the infused urinary bladder of unanaesthetized rabbits. Following the injection of emeprone and PR 197 (1–4 mg/kg intravenously) the bladder volume capacity increased and the micturition pressure decreased. These drugs also produced a residual volume after micturition. No change in the micturition threshold pressure could be detected. Atropine (1–4 mg/kg intravenously) caused a marked decrease in the bladder volume capacity, micturition pressure, and micturition threshold pressure, but did not produce any residual volume. The results obtained in the present investigation using unanaesthetized animals differed from similar experiments, where anaesthetized animals were used. It is concluded that the peripheral actions of the substances used were confined mainly to the cholinergic receptors in the urinary bladder. The different response after atropine was attributed to its central stimulating effect.