Abstract
Introduction It is well established that upon synthesis, FVIII enters the ER to be folded and transported to the ERGIC compartment by interacting with chaperones and cargo proteins (ER: CANX and CALR; ERGIC: LMAN1 and MCFD2) which constitute the conventional secretory pathway (1). The highly similar ATG8 homolog proteins, GABARAP, GABARAPL1 and GABARAPL2 are gaining high interest due to the many roles that they play, in autophagy related and autophagy non-related functions (2). Albeit highly similar, these proteins seem to play differential roles that still require much investigation (3). We hypothesize that GABARAPs play a role in the intracellular trafficking of FVIII. However, due to the high similarity between these proteins and possible compensation among them, it is difficult to distinguish individual functions (4).
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