Abstract
Male Wistar rats received dexamethasone (1.5 mg/kg/day) hind-limb injections for 2.5 weeks (D—2.5 wk, N = 10) and 10 weeks (D—10 wks, N = 9). Controls were pair-fed and injected daily with saline solution. All groups had similar weights initially (186 ±2 g). Pneumonia was not a complication. Hemidiaphragm costal strips were bathed in modified Krebs (37°C) containing insulin and d-tubocurarine. At optimal length, isometric twitch (2ms, sq wave) and tetanic tensions (400 ms trains at 10, 20, 60, and 100 Hz), normalized for muscle strip csa (g/cm2), were measured at baseline BI, after 10 min of fatiguing stimulation (5 impulses at 5 Hz; 30 trains/min) and after 10 min of recovery.
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