Abstract
Aim: Changes in the iron level in the myocardium may be affected by sodium and potassium channels in myocytes and there may be a contribution to the etiology of cardiac arrhythmia. The aim of this study was to examine for the first time in literature how the Tp-e interval, which has been accepted in recent years as a strong ventricular repolarisation index, is affected in female patients with severe iron deficiency anemia. Material and Methods: The study included a total of 64 participants, as a study group of 34 patients diagnosed with severe iron deficiency anemia (Hgb<8g/dL Ferritin<14 mcg/L, MCV<80 mm3) and a control group of 34 subjects. To determine the QTc and Tp-Te interval durations, manual examination was made of manual precordial V5 lead ECGs taken routinely on the presentation of all participants. Results: The Tp-e interval was determined to be statistically significantly shorter in the patients (78.97 ± 8.63 ms) compared to the control group (84.57 ± 10.13 ms) (p<0.05). A positive relationship was determined between Tp-e and QTc durations and Hgb and ferritin levels (p<0.05). Conclusion: The results of the study showed that the QTc duration and the Tp-e duration were shorter in female patients with iron deficiency anemia, and therefore iron deficiency anemia can be discounted as a cause of prolonged QTc and Tp-e durations.
Highlights
Iron deficiency anemia is the most common cause of anemia worldwide
A positive relationship was determined between Tp-e and QTc durations and Hgb and ferritin levels (p
The results of the study showed that the QTc duration and the Tp-e duration were shorter in female patients with iron deficiency anemia, and iron deficiency anemia can be discounted as a cause of prolonged QTc and Tp-e durations
Summary
Iron deficiency anemia is the most common cause of anemia worldwide. The morphological characteristics of the T-wave have become a focus of increasing interest. The components of T-wave morphology have been shown to be relatively independent of pulse rate, in contrast to the QT interval. The Tp-e interval duration can be defined as a transmural dispersion index of repolarisation and in this context, it can be used as a predictive marker for the risk of developing life-threatening arrhythmia [5,6]. As an abnormal function of the Na+ and K+ channels may contribute to the etiology of cardiac arrhythmia such as prolonged QT syndrome, the aim of this study was to compare the TP-e and QT intervals in female patients with severe iron deficiency anemia and a control group
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