Abstract
Objective: Gallbladder stones are common in the Western world, and 70% to 80% of gallstones are cholesterol stones. This study investigates the effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration. Methodology: The gallstones of 75 patients with cholelithiasis were examined using spectrophotometry. Results: High serum cholesterol and LDL levels were associated with high cholesterol stone rates (86.7% vs. 40.0%, P < 0.001; 75.0% vs. 48.9%, P < 0.05, respectively). Similarly, high serum cholesterol and LDL levels were correlated with high gallbladder stone cholesterol concentrations (63.6% vs. 44.4%, P < 0.001; 62.3% vs. 46.0%, P < 0.001, respectively). In contrast, low serum HDL levels do not seem to affect the occurrence of gallbladder cholesterol stones (60.0% vs. 58.3%, respectively, P > 0.05) or gallbladder stone cholesterol concentrations (50.8% vs. 52.4%, respectively, P > 0.05). Conclusion: The relationship between cholesterol, LDL, and HDL levels and cholesterol gallstone formation is multifactorial and complex and is also dependent on other individual properties.
Highlights
Gallbladder stones are common in the Western world with an incidence of 1.4 per 100 personyears.[1]
This study investigated the effects of serum cholesterol, Low-density lipoproteins (LDLs), and high-density lipoproteins (HDLs) levels on the cholesterol concentration of gallstones in patients with cholelithiasis
Cholesterol stones were identified in 44 patients (58.7%), and the stone cholesterol concentrations were between 9% and 91%
Summary
Gallbladder stones are common in the Western world with an incidence of 1.4 per 100 personyears.[1]. Its major synthesis site is the liver, and its only excretion site is the biliary system.[2] The pathogenesis of cholesterol gallstones is multifactorial and complex. The known factors associated with cholesterol gallstones include cholesterol hypersecretion and supersaturation, bile salt and phospholipid concentrations, crystal nucleation, gallbladder dysmotility and gallbladder absorption and secretion functions.[2,3,6,7] Low-density lipoproteins (LDLs) and high-density lipoproteins (HDLs) are plasma lipids, and their main function is to transport cholesterol. LDL transports cholesterol from the liver to the peripheral tissues, and HDL transports cholesterol from the peripheral tissues to the liver.[2]
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