The Effects of Resistance and Endurance Training on Levels of Nesfatin-1, HSP70, Insulin Resistance and Body Composition in Women with Type 2 Diabetes Mellitus

Abstract

Summary Objectives Nesfatin-1 and HSP70 are involved in the regulating mechanisms of insulin and glucose metabolism. The aim of this study was to evaluate the effects of 10 weeks of resistance and endurance exercise training on the serum levels of nesfatin-1, HSP70 and insulin resistance (IR) in women with type 2 diabetes. Materials and Methods 26 women with type 2 diabetes were selected using purposive sampling and were randomly divided into three groups. 10 subjects participated in the resistance training group (3 sessions per week, exercising with 30–80% of one repetition maximum (1RM)), 8 subjects participated in the endurance training group (3 sessions per week, exercising with 40–80% of maximum heart rate (HR max), for 20–45 minutes), and 8 subjects were placed in the control group who did not engage in any physical exercise during the study period. Blood samples were collected after a 12 hour [overnight] fast in order to evaluate nesfatin-1, HSP70, insulin and glucose levels in the pre- and post-tests. The obtained data were analyzed using the Kolmogorov-Smirnov (K-S) test, paired-samples t-test, one-way ANOVA and LSD post-hoc test in SPSS software, version 21 at the significance level of α Results There was a significant increase in nesfatin-1 levels and a significant decrease in HSP70 levels of the resistance training group, (P 0.05). Glucose levels, insulin resistance (HOMA1-IR) and body composition indices (except for WHR) significantly decreased in both training groups (P 0.05). Moreover, comparing the pre- and post-test levels of glucose changes, a significant difference was observed in the resistance and endurance training groups but not in the control group (P Conclusion Resistance and endurance training are recommended as complementary therapy for women with type 2 diabetes mellitus.