The Effects of Renal Nerve Denervation on Blood Pressure and Target Organs in Different Hypertensive Rat Models.

Demin Liu,Guoqiang Gu,Haijuan Hu,Ruiqin Xie,Wei Cui,Rui Ding,Jing Wang,Tomohiro Katsuya

doi:10.1155/2021/8615253

Abstract

Background Hypertension contributes to the progression of cardiac remodeling and renal damage. In turn, renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients. The purpose of this study was to observe the effect of renal nerve denervation on blood pressure and target organ changes in two hypertensive rat models. Methods Hypertensive rats were randomly divided into a renal denervation (RDN) group and sham operation group. Wistar–Kyoto (WKY) rats of the same age were set as the baseline control group. In the secondary hypertension model, SD rats were randomly divided into five groups. Blood pressure and bodyweight were measured every week until they were euthanized. Results The two rat models underwent RDN at key timepoints. At these timepoints, the hearts and kidneys were collected for norepinephrine and angiotensin II measurements and histological analysis. Conclusion RDN performed before development of hypertension showed a significant antihypertensive effect on the secondary hypertension model.

Highlights

Hypertension contributes to the progression of cardiac remodeling and renal damage
In the spontaneously hypertensive rat (SHR) rats, there was no significant difference in bodyweight between the renal denervation (RDN) group and sham group at the corresponding point of time
In 2014, SYMPLICITY HTN-3 was used as the first double-blind randomized trial and it failed to reach its primary endpoint of the antihypertensive effect [8, 16], which has caused a decline in interest for RDN research

Summary

Introduction

Hypertension contributes to the progression of cardiac remodeling and renal damage. In turn, renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients. e purpose of this study was to observe the effect of renal nerve denervation on blood pressure and target organ changes in two hypertensive rat models. Renal sympathetic hyperactivation showed elevated sympathetic nervous system activity and led to blood pressure increase in certain patients. E purpose of this study was to observe the effect of renal nerve denervation on blood pressure and target organ changes in two hypertensive rat models. In the secondary hypertension model, SD rats were randomly divided into five groups. Hypertension is associated with increased sympathetic activation, possibly contributing to the progression of cardiac remodeling and renal damage [1]. RDN as an interventional approach to target elevated sympathetic nervous system activity has received considerable interest, as it has led to blood pressure (BP) reduction in certain patients with uncontrolled hypertension [3, 4]. A suitable, hypertensive animal model with long-term follow-up would greatly help to further assess BP effects and other surrogate markers of efficacy in detail, such as histological RDN and renal norepinephrine content [13]

Objectives

Methods

Results

Discussion

Conclusion