The effects of recombinant human basic fibroblast growth factor on nerve regeneration in a partial defect inferior alveolar nerve model in rabbits

Abstract

ObjectiveThe purpose of this study was to investigate the effect of recombinant human basic fibroblast growth factor (rhbFGF) on nerve regeneration immediately after nerve injury. MethodPartial defects were created in the inferior alveolar nerve of rabbits and were treated with (Experimental group) or without (Control group) rhbFGF for 1–3 weeks. Injured tissues were then characterized immunohistochemically using primary antibodies to S-100; a marker for Schwann cells, and to neurofilament (NF); a marker for axons. ResultsThe number of S-100-immunopositive cells in the experimental group was significantly increased compared with the control group at weeks 2 and 3 (P < 0.05). The number of NF-immunopositive cells in the experimental group was also significantly increased compared with the control group at week 3 (P < 0.05). ConclusionThese results suggest that application of rhbFGF immediately after partial damage of an inferior alveolar nerve might be effective to promote nerve regeneration.