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Abstract
The incidence of Sister Chromatid Exchanges (SCE’s) due to β radiation was investigated in cultured human lymphocytes using the BrdU/Giemsa technique. Cultures treated continuously with 0.001 and 0.01 μ Ci of 3 H-Uridine showed no increase in either chromosome abnormalities or SCE’s. Continuous treatment with 0.1 μ Ci resulted in a significant increase in chromosome aberrations but no increase in SCE’s while treatment with 0.2 μ Ci gave both an increase in chromosome aberrations and SCE’s. Cultures given a 4 h pulse with 1.0 μ Ci showed a significant increase in both SCE’s and chromosome aberrations. The results indicate that low levels of β radiation do not cause an increase in SCE’s in human lymphocytes, and that a number, if not all, of the exchanges observed at low levels of β radiation with autoradiography, may be spontaneous events.
Published Version
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