Abstract
Eighteen normotensive and 19 unmedicated hypertensive black and white male subjects were studied twice, during a 10 meq sodium diet for 5 days and a 200 meq sodium diet for 4 days. The subjects received an infusion of 3H-norepinephrine ( 3HNE) during both low and high sodium diets to measure NE clearance. Dietary sodium and blood pressure classification had no effect on 3HNE clearance. Infusion of pressor doses of NE also failed to alter 3HNE clearance. Both normotensive and hypertensive blacks had increased 3HNE clearance rates (p < .001). The increased rate of 3HNE clearance among blacks was not affected by alterations in dietary sodium or by pressor doses of NE. Increased NE clearance by blacks may help explain obser-vations that white hypertensives in the age range we studied (25–46 years) have elevated plasma NE levels, while blacks have normal NE levels.
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