Abstract
THE ACTION of pepsin and trypsin on pituitary gonadotropic hormones hasbeen studied on several occasions, but in the hands of various investigators tryptic digestion of pituitary extracts has yielded divergent results.Bates, Riddle and Lahr (i) and Fevold (2) reported complete inactivation ofpituitary FSH when treated with a commercial preparation of trypsin, whileMcShan and Meyer (3), Chen and van Dyke (4) and Greep (5) found thatLH but not FSH was destroyed by this enzyme. Fevold (2) had previouslyreported the inactivation of LH by means of trypsin. McShan and Meyeremployed both commercial and crystalline trypsin, while the remainingauthors used various commercial tryptic preparations. Recently, Chow,Greep and van Dyke (6) found that crystalline trypsin was more effectivethan commercial trypsin in destroying the activity of an anterior pituitaryextract containing the gonadotropic hormones.The differential lability of FSH and LH to tryptic actionTHE ACTION of pepsin and trypsin on pituitary gonadotropic ...
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