Abstract
We studied changes in the contents of the transcription factors NF-kB and Fos, the apoptosis regulating factors bax and bcl-xl, and a marker of astroglial activity, viz., the glial fibrillar acidic protein, in the spinal cords of rats with experimental streptozotocin-induced diabetes. We found that shifts in the levels of these factors after induction of diabetes may be partially prevented by administration of the protein kinase C (PKC) inhibitors chelerythrine hydrochloride and rottlerin. Our data show that these substances are promising drugs for the correction of diabetic neuropathy. PKC isoenzymes contribute to pathogenesis of diabetic neuropathy differently; therefore, the development of selective inhibitors for specific PKC isoenzymes may improve their efficacy and decrease the probability of the appearance of side effects.
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