Abstract
The effects of prostaglandin E 2 (PGE 2) on cyclic AMP levels in various mouse lymphocyte populations were studied.It was found that spleen cells and thymocytes respond comparably to PGE 2. Cortisone treatment abolished the responsiveness in thymocytes. Fractionation of splenic lymphocytes on glass wool columns into subpopulations of bone-marrow derived (B) cells or thymus-derived (T) cells showed that both B and T splenic lymphocytes can respond to PGE 2. Lymphocytes or spleen cells cultured for varying periods (24–96 hrs) lose their sensitivity to PGE 2 stimulation of cAMP. This “refractoriness” to PGE 2 is only partially reversed by incubating lymphocytes with phosphodiesterase inhibitors.
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