Abstract
The effects of prostacyclin (PGI 2) and its stable metabolite 6-oxo-PGF 1α on various bioassay tissues are compared with those of PGE 2 and PGF 2α, using the cascade superfusion method. On vascular smooth muscle, PGI 2 caused relaxation of all tissues tested except the rabbit aorta. PGE 2 relaxed rabbit coeliac and mesenteric artery but contracted bovine coronary artery and had no effect on rabbit aorta. 6-oxo-PGF 1α was ineffective at the concentrations tested. On gastro-intestinal smooth muscle, PGI 2 contracted strips of rat and hamster stomach and the chick rectum. It was less potent than PGE 2 or PGF 2α. None of these substances contracted that cat terminal ileum. 6-oxo-PGF 1α was inactive on these tissues at the doses tested. PGI 2 was less active than PGE 2 or PGF 2α in contracting guinea-pig trachea and rat uterus; 6-oxo-PGF 1α was active only on the rat uterus. Thus, PGI 2 can be distinguished from the other stable prostaglandins using the cascade method of superfusion.
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