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Abstract
Estrogen-primed female rats were administered progesterone, 5 a-pregnan-3,20-dione, 5 a-pregnan-3 a-ol-20-one, 5 a-pregnan-3β-ol-20-one, 4-pregnen-20 a-ol-3-one, and 5 a-pregnan-20 a-ol-3-one in oil or oil alone and tested for the display of lordosis behavior 3 and 5 hr after progestin treatment. Progesterone was the most effective progestin in facilitating lordosis behavior. 5 a-Pregnan- 3,20-dione and 5 a-pregnan-3 a-ol-20-one were partially effective, while the other progestins were no more effective than oil. The data suggest that the neuronal system which controls lordosis behavior is not entirely specific for progesterone.
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