Abstract
The prevalence of maternal obesity and gestational diabetes mellitus (GDM) is increasing rapidly. Probiotics supplementation have been shown to improve metabolic health in humans. In our study, we aimed to evaluate the effects of probiotics supplementation on metabolic health and pregnancy complications in pregnant women. The literature search, data extraction and quality assessment were performed, and data were synthesized in accordance with standardized guidelines. Ten randomized clinical trials with eligible data were included in our meta-analysis. For pregnant women with GDM, we found negative correlations between probiotics supplementation and fasting serum insulin (OR -2.94, 95%CI [-5.69, -0.20], p = 0.04) and homoeostasis model assessment for insulin resistance (HOMA-IR) (OR -0.65, 95%CI [-1.18, -0.11], p = 0.02). There were no significant correlations between probiotics supplementation and lipid levels in women with GDM, including total cholesterol (OR -2.72, 95%CI [-17.18, 11.74], P = 0.71), high density lipoprotein cholesterol (HDL-c) (OR -0.29, 95%CI [-3.60, 3.03], P = 0.87), low density lipoprotein cholesterol (LDL-c) (OR -0.38, 95%CI [-18.54, 17.79], P = 0.97), or triglycerides (OR -12.83, 95%CI [-36.63, 10.97], P = 0.29). For healthy pregnant women, probiotics supplementation were negatively associated with fasting serum insulin (OR -3.76, 95%CI [-4.29, -3.23], P < 0.00001) and HOMA-IR (OR -0.57, 95%CI [-1.08, -0.06], p = 0.03). However, no significant correlations were observed between probiotics supplementation and fasting plasma glucose (FPG) (OR -2.02, 95%CI [-5.56, 1.52], p = 0.26). Thus, our study revealed that probiotics supplementation during pregnancy have beneficial effects on glucose metabolism, rather than lipid metabolism among pregnant women.
Highlights
The prevalence of obesity and type 2 diabetes mellitus (T2DM) in adulthood is increasing dramatically [1]
For pregnant women with gestational diabetes mellitus (GDM), we found negative correlations between probiotics supplementation and fasting serum insulin (OR -2.94, 95% confidence intervals (CIs) [-5.69, -0.20], p = 0.04) and homoeostasis model assessment for insulin resistance (HOMA-IR) (OR -0.65, 95%CI [-1.18, -0.11], p = 0.02)
We identified 88 potentially eligible literatures and 68 were kept after removing duplicates. 44 articles were excluded due to preclinical studies, reviews or conference abstracts or case reports or editorials or book chapters or observational studies. 24 potential studies were further reviewed after reading the full article
Summary
The prevalence of obesity and type 2 diabetes mellitus (T2DM) in adulthood is increasing dramatically [1]. The pathogenesis of diabetes mellitus has not been fully demonstrated. Increasing evidence shows that maternal environment, especially metabolic status during. Probiotics supplementation on metabolic health in pregnant women. Education (No 201506210378), Postgraduate Student Innovation Fund in Peking Union Medical College (No 2013-1002-33). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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