Abstract
Des-, mono-, and diacetylated melanotropin (des-, mono-, and di-Ac MSH, respectively) were compared for their dose-related effects on content of adenosine 3′:5′-monophosphate (cAMP) and tyrosinase activity in the Cloudman S91 mouse melanoma tumor. Des-Ac MSH was more potent than the acetylated forms of MSH at increasing cellular levels of cAMP; mono- and di-Ac MSHs, however, were more potent than des-Ac MSH at elevating the activity of the enzyme, tyrosinase. Lysine-gamma 1 MSH, a melanotropin from the amino terminus of pro-opiomelanocortin, exhibited slight stimulatory effects on tyrosinase and these actions were less than additive to those of mono-Ac MSH. Unlike their action on amphibian skin-darkening or in mammalian behavior, neither β-endorphin 1–31 nor its derivatives, N-Ac-β-endorphin 1–27 or β-endorphin 30–31 (glycyl-glutamine), exhibited any influence on tyrosinase activity evoked by mono-Ac MSH in the tumor cells.
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