Abstract
The effects of priming immersions in various human gamma globulin (HGG) vaccines on the humoral and cell-mediated immune responses following a subsequent intraperitoneal challenge of HGG in adjuvant were investigated. The cell-mediated immune response was assessed by measuring chemotactic factor production by pronephric cells after in vitro stimulation with HGG, using the micro chemotaxis method. Serum antibody levels were measured using the passive haemagglutination technique. Immersions in latex particle-bound HGG (HGG-latex) stimulated a greater humoral immune response, post-challenge, than immersions in soluble HGG although this effect of antigen particle size was not noticeable in the cell-mediated immune response. Immersions in soluble HGG opsonised with anti-HGG immune carp serum stimulated a greater humoral immune response, post-challenge, than priming immersions in either a control bath, from which antigen was omitted, or non-opsonised soluble HGG. Immersions in HGG-latex opsonited with anti-HGG immune carp serum stimulated both greater humoral and greater cell-mediated immune responses, post-challenge, than immersions in either a control bath, soluble HGG, HGG-latex or HGG-latex opsonised with normal carp serum.
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