Abstract
Insulin resistance and diabetes mellitus are common consequences of iron overload in the pancreas of beta-thalassemia major (BTM) patients. Moreover, postprandial blood glucose elevations are linked to major vascular complications. The purpose of this study was to investigate the effects of a bout of acute resistance exercise following breakfast consumption of glucose and fat on the metabolism in prediabetic, BTM patients. Six patients underwent two trials (exercise and control) following breakfast consumption (consisting of approximately 50% carbohydrates, 15% proteins, 35% fat), in a counterbalanced order, separated by at least three days. In an exercise trial, patients performed chest and leg presses (3 sets of 10 repetitions maximum/exercise), while in the control trial they rested. Blood samples were obtained in both trials at: pre-meal, 45 min post-meal (pre-exercise/control), post-exercise/control, 1 h post-exercise/control, 2 h post-exercise/control and 24 h post-exercise/control. Blood was analysed for glucose and lipids (total cholesterol, High Density Lipoprotein-cholesterol, Low Density Lipoprotein-cholesterol, triglycerides). Blood glucose levels increased significantly 45 min following breakfast consumption. Blood glucose and lipids did not differ between trials at the same time points. It seems that a single bout of resistance training is not sufficient to improve blood glucose and fat levels for the subsequent 24-h post-exercise period in prediabetic, BTM patients.
Highlights
Prediabetes is as a state of intermediate hyperglycaemia where a person has impaired fasting glucose, impaired glucose tolerance or a combination of the two [1]
The main aim of this study was to examine whether postprandial resistance exercise can influence changes in blood glucose in prediabetic, beta-thalassemia major (BTM) patients
Our findings suggest that an acute bout of postprandial resistance exercise is not a sufficient stimulus to (i) attenuate the blood glucose response, and (ii) change the lipids profile, throughout the subsequent 24-h post-exercise period
Summary
Prediabetes is as a state of intermediate hyperglycaemia where a person has impaired fasting glucose, impaired glucose tolerance or a combination of the two [1]. Individuals with prediabetes are at high risk of developing DM [2]. Lifestyle interventions have been shown to reduce the risk of DM in adults with prediabetes, and they should be an essential part of the management of this condition. The main problem in glycaemic control is the peak of glucose 1–2 h after a meal, i.e., postprandial hyperglycaemia. Exercise increases contraction-mediated glucose uptake resulting in reduced postprandial hyperglycaemia and has been proposed as an effective way to improve glucose control in individuals with type 2 DM.
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