Abstract
Cancer is closely associated with aging of the body. Aging of the extracellular matrix (ECM) leads to a fibrotic microenvironment and increasing stiffness of ECM. In this study, the porosity and stiffness were advantageous to the proliferation and aggregation of ovarian SKOV-3 cancer cells. Both the porosity and stiffness increase could lead to enhancement of proliferation and aggregation of ovarian SKOV-3 cancer cells. Further studies aimed at preventing tumoral invasion and metastasis should focus on drugs that can prevent age-induced degenerative changes in the ECM.
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