Abstract
Abstract The thermal transition profile (melting profile) of the double-helical complex of polyriboinosinic acid plus polyribocytidylic acid, poly(I+C), into random coils in solution has been examined by the observation of the ultraviolet absorbance at 248 mμ of the solution. The effects of Na+, Mg2+, NH4+, CH3NH3+(CH2)nNH3+ (where n=2, 3, 4, 5, 6, and 8), spermidine, spermine, actinomycin D, and poly-l-lysine upon the melting profile have been observed. Among the diamines examined, that with n=3 has been found to have the maximum effect. Poly-l-lysine has been found to form a complex with poly(I+C) in the solution with a stoichiometric mole ratio of NH2 : P=0.5 : 1.
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