Abstract
In tests of the effects of the psychotomimetic agent, phencyclidine, 1-(1-phenylcyclohexl) peperidine (PCP), on the uptake of 3H-catecholamines by synaptosome-rich homogenates of rat striatum and hypothalamus, PCP was shown to be a potent, competitive inhibitor of both 3H-dopamine uptake in the striatal region and 3H-norepinephrine uptake in the hypothalamus. The implication of these findings are discussed in terms of a drug-induced imbalance of the catecholaminergic-cholinergic systems in those regions of the brain where activity has been correlated with emotional expression.
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