Abstract

Objective To observe the functional change of perivascular adipose tissue in spontaneously hypertensive rats(SHRs). Methods Thoracic aorta was divided into two subgroups: vessel without perivascular adipose tissue subgroup and vessel with perivascular adipose tissue subgroup. The contractile force in two subgroups induced by phenylephrine were compared. We compared the differences of contractile force in two subgroups of WKY group and SHR group. By means of transfer, we observed the effect on vessel without perivascular adipose tissue in WKY caused by the bath solution from perivascular adipose tissue vessel. Results The contractile force of perivascular adipose tissue subgroup in WKY group was lower than that in subgroup without perivascular adipose tissue (P 0.05).The bath solution transferred from perivascular adipose tissue subgroup in WKY could led to a quick relaxation of vascular without perivascular adipose tissue. Conclusions The perivascular adipose tissue in WKY might decrease the responsiveness to phenylephrine of vessel, and it depend on perivascular adipose tissue releasing a transferable vessel relaxation factor. The function aboved of perivascular adipose tissue in SHR was inhibited. The pathological mechanisms of hypertension might involve the dysfunction of perivascular adipose tissue. Key words: Perivascular adipose tissue; Adventitial-derived relaxing factor; Hypertension

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