Abstract
To study the effects of past exposure to TORCH on pregnancy and neonatal outcomes after IVF/ICSI-ET. A retrospective cohort study. 18741 IVF/ICSI-ET cycles. Patients undergoing IVF/ICSI-ET from January 1st,2010 to December 31st, 2016 in our hospital, with no infection to TORCH (IgM(-) IgG(-)) or with past exposure to TORCH (IgM(-)IgG(+)), were enrolled. Outcomes of clinical pregnancy, ectopic pregnancy, miscarriage, live birth, preterm birth, malformation and perinatal death were evaluated between the TORCH past exposure group and the no infection group. Patients with past exposure to CMV had a statistically significantly decreased live birth rate in comparison to the no CMV infection group (P=0.004, OR=0.743[95% CI, 0.605-0.912], Adjusted OR=0.852 [95%CI, 0.762-0.952]). Besides, in regard to TOXO, past exposure to TOXO lowered the preterm birth rate (P=0.082, OR=0.615[95% CI, 0.354-1.070], Adjusted OR=0.677 [95%CI, 0.489-0.937]), yet increased the neonatal minor malformation rate (P=0.091, OR=4.209[95% CI, 0.986-17.968], Adjusted OR=2.171 [95%CI, 1.046-4.507]). No differences in clinical pregnancy, ectopic pregnancy, miscarriage, and perinatal death were noticed between the corresponding TORCH pathogen past exposure group (IgM(-) IgG(+)) and the no infection group(IgM(-) IgG(-)). CMV past infection had an adverse effect on live birth rate, and TOXO past infection increased the incidence of malformation in offspring after IVF/ICSI-ET.Our study provides the first evidence of a correlation between past exposure to TORCH and the pregnancy and neonatal outcomes after IVF/ICSI-ET, which may shed new lights on the ART clinical practice.
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