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Abstract
AbstractThe physiology of Streptomyces clavuligerus has been studied by investigating oxygen uptake and β‐lactam (clavulanic acid) production by free and alginate entrapped cells. The specific oxygen uptake rate of cells entrapped in strontium or calcium alginate was only about 35% of the rate in free cells. This reduction in oxygen uptake was due to reduced internal diffusion of oxygen; in addition calcium, barium and strontium ions could also cause oxygen uptake in free cells to be inhibited. Measurements of the deformation of individual gel beads showed that maximum hardness was reached after 15 min exposure to 0.14 mol dm−3 Ca2+. Exposure of cells to Ca2+ for this time caused a 15% reduction in the rate of oxygen uptake. Levels of clavulanic acid produced by free cells were higher than those produced by immobilized cells; production was dependent on the degree of aeration of the cells.
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