The effects of oral steroid therapy on prolidase enzyme activity in patients with nasal polyps

Adnan Ekinci,Muge Ozcan,Emre Demir,Huseyin Kayadibi

doi:10.1515/tjb-2019-0204

Abstract

Abstract Objective To compare prolidase enzyme activity (PEA) in serum and polyp specimens of patients with nasal polyps obtained before and after the oral steroid therapy. Materials and methods Thirty three patients with nasal polyps (39 ± 13 years) received 1 mg/kg of oral steroids. Serum samples were collected from each patient, but nasal polyp specimens could be obtained only from 23 patients (38 ± 13 years) before and after the oral steroid therapy. PEA was measured by ELISA method. Results Serum PEA values were 210 (176–242) U/L and 184 (147–217) U/L before and after the oral steroid therapy, respectively (p = 0.015). Polyp tissue PEA was 1337 (738–2130) U/g and 871 (590–1663) U/g before and after the oral steroid therapy, respectively (p = 0.429). Conclusion In patients with nasal polyps, significantly lower serum PEA after the oral steroid therapy may be a consequence of the role of prolidase enzyme in inflammatory processes which are important for the development of nasal polyps. More comprehensive studies with larger sample sizes are needed to elucidate the role of PEA in the pathogenesis of nasal polyps.

Highlights

IntroductionNasal polyps (NPs) that occur as a result of the chronic inflammation in nasal cavity and paranasal sinuses are
Nasal polyps (NPs) that occur as a result of the chronic inflammation in nasal cavity and paranasal sinuses areThis work is licensed under the Creative Commons Attribution 4.0Adnan Ekinci et al.: The effects of oral steroid therapy on prolidase enzyme activity the inflammatory outgrowths of upper respiratory tract [1]
In patients with nasal polyps, significantly lower serum prolidase enzyme activity (PEA) after the oral steroid therapy may be a consequence of the role of prolidase enzyme in inflammatory processes which are important for the development of nasal polyps

Summary

Introduction

Nasal polyps (NPs) that occur as a result of the chronic inflammation in nasal cavity and paranasal sinuses are. Growth factors, chemical mediators and inflammatory cells cause the development of nasal mucosal inflammation and edema which are the leading cause of NPs [3, 4]. In the development of NPs, chronic inflammation is followed by mucosal epithelial proliferation, mucosal thickening, myofibroblast differentiation, extracellular matrix (ECM) deposition and fibrosis [5, 6]. Increased plasma prolidase activities have been observed elevated in situations that are characterized by chronic inflammation of the tissue and/or increased collagen turnover. There is no published study for PEA both in serum and nasal polyp tissue before and after the therapy with steroids in patients with NPs. we aimed to determine the levels of PEA in serum and polyp specimens of these patients before and after the oral steroid therapy

Materials and methods

Results

Discussion

Findings

Conclusion