Abstract
We studied the effects of subchronic administration of various nootropic drugs, such as piracetam, phenotropil, noopept, semax, pantogam, and nooglutil on the neurochemical characteristics of metabotropic glutamate mGluRII receptors in the brains of inbred BALB/c and C57BL/6 mice, which differed in their initial indices of exploratory behavior, anxiety, and locomotor activity. We found that in the brain of the C57BL/6 mice, the Bmax value was 15–20% higher compared to the BALB/c mice. Five daily equipotential doses of the drugs did not influence the Bmax value in all groups of the BALB/c mice, whereas administration of piracetam, noopept, and semax to C57BL/6 mice decreased the density of binding sites for [3H]-LY354740 by 21, 19, and 18%, respectively. Pantogam and nooglutil did not affect mGluRII binding, suggesting that these drugs have specific mechanism of nootropic action.
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