Abstract
Some non-steroid anti-inflammatory drugs which inhibit arachidonate cyclo-oxygenease have been examined for their effects on leukocyte migration, prostaglandin production and oedema formation in carrageenin-induced inflammation in the rat. At doses which inhibited oedeman, all the drugs tested caused a dose-dependent reduction in numbers of leukocytes and prostaglandin concentration in 24-h inflammatory exudates. At lower doses, indomethacin, aspirin, sodium salicylae, flurbiprofen and phenylbutazone isgnificantly potentiated leukocyte migration by 20–70%. Ibuprofen, naproxen and BW755C reversed the indomethacin-induced increase in leukocyte accumulation. BW755C inhibits the generation of chemotactic lipoxygenase products and it is possible that the effects of all these drugs on leukocyte migratoin are mediated though the lipoxygenase pathway of arachidonic acid metabolism.
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