The effects of nominal absorption in bone on the extinction lengths for scattering, absorption, and overall attenuation

Abstract

In cortical bone, the effect of absorption in the solid matrix on ultrasound scattering and propagation is not well understood, and for absorption, it is not easily incorporated into simulations and is difficult to measure independently from scattering attenuation. In this study, finite-difference time-domain simulations were conducted in maps derived from scanning acoustic microscopy images of human femur cross-sections. These maps were modified by controlling pore density (fixed at 10 pores/mm2) and diameter distribution (ranging between 30 and 100 μm). Eight nominal absorption values, ranging from 0 to 100 dB/cm, were attributed to the solid matrix. Absorption in the pores was set to 0.01 dB/cm. Propagation of ultrasound pulses centered at 8 MHz was simulated in both backscattering and through-transmission configurations. The scattering, absorption, and overall attenuation extinction lengths were obtained. T-tests demonstrated that varying the absorption significantly impacts the extinction lengths for scattering, overall attenuation, and absorption. The differences in values for the scattering, attenuation, and absorption extinction lengths when absorption varied from 20 to 40 dB/cm are statistically significant (respective p-values: 9.1 × 10−14, 3.3 × 10−5, and 8.8 × 10−5). It was also demonstrated that attenuation due to scattering dominates overall attenuation at low-nominal absorption values, whereas the converse is true at higher absorption values.