Abstract
(Anesth Analg. 2021;132:231–239) During delivery, nitroglycerin is used clinically to reduce uterine tone, in situations such as uterine hyperstimulation or difficult fetal extraction. Oxytocin (OT) is an uterotonic used to induce contractions and after delivery to prevent postpartum hemorrhage. OT exposure in myometrium can cause desensitization of OT receptors. A previous study by Lau et al1 found OT can achieve satisfactory uterine tone following the use of nitroglycerin myometrium in vitro, but it is not clear if the use of nitroglycerin affects the dose needed to reestablish uterine tone. This in vitro study investigates whether nitroglycerin alters the OT dose-response in OT-desensitized and OT-naive tissues.
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