Abstract
The purpose of the study was to compare the peripheral vascular effects of the calcium blocker nifedipine (NF) in normotensive Wistar Kyoto (WKY; n = 25) rats and spontaneously hypertensive rats (SHR; n = 28). Male eighteen week old animals were anesthetized with pentobarbital (50 mg/kg i.p.) and subjected to the radioactive microsphere technique for measurement of systemic and regional hemodynamics. While NF (30 micrograms/kg i.v. or 100 micrograms/kg i.v.) was effective in reducing resistance in all sampled vascular beds of SHR and WKY, it reduced renal vascular resistance to a greater extent in the SHR than in WKY (p less than 0.025). The data suggested a similar strain-specific effect in the SHR coronary, stomach and brain vasculatures (0.12 less than p less than 0.16). By contrast, high dose NF had a preferential effect on the skeletal muscle vasculature of WKY (p less than 0.025 for blood flow, p less than 0.16 for resistance). The findings support the premise that each calcium blocker has unique regional effects that differ between SHR and WKY.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Clinical and experimental hypertension. Part A, Theory and practice
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
